This bundle is the result of several individual studies each analyzing different factors, such as pain, spontaneous awakening trials or SATs, spontaneous breathing trials or SBTs, delirium, choice of drug, and early mobility. This slide defines the ABCDEF bundle acronym. “A” represents the assessment, prevention, and management of pain. “B” represents both SATs and SBTs. “C” represents the choice of sedation. “D” represents delirium to be assessed, prevented, and managed. “E” represents the early mobility and exercise of patients. Finally, “F” represents family engagement and empowerment.